Domenico Brunetti was an Italian musician and organist.
He was Chapel Master in Bologna Cathedral, and he was one of the first composers to publish accompanied monodies. L'Euterpe (1606) contains monodic madrigals and arias as well as duets and trios that can be performed a capella or with continuo. In the vocal solos, duos and trios of the Concentus cum gravi et acuto ad organum (1609) the instrumental bass part includes a written out part ofr the right hand, which is sometimes melodic but otherwise harmonically conceived. Brunetti founded the Accademia dei Filaschisi in 1633.